Search Result
Results for "
imidazole derivative
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
10
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-106542A
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Fungal
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Infection
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Eberconazole nitrate is a dichlorinated imidazole derivative with antifungal activity. Eberconazole nitrate is more active than Clotrimazole, Ketoconazole, and Miconazole. Eberconazole nitrate has the potential for the research of dermatophytoses with a topical administration .
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- HY-D0837
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Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene
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Endogenous Metabolite
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Others
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Imidazole, a highly polar compound containing planar five-membered rings, has been widely used as a corrosion inhibitor. Derivatives of Imidazole have antimicrobial, anti-inflammatory, and antitumor activities .
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- HY-W720736
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Others
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Cardiovascular Disease
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Tinazoline, imidazole derivative, is a vasoconstrictor. Tinazoline can as nasal decongestant for the research of common cold .
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- HY-106542
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Fungal
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Infection
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Eberconazole is a dichlorinated imidazole derivative with antifungal activity. Eberconazole is more active than Clotrimazole, Ketoconazole, and Miconazole. Eberconazole has the potential for the research of dermatophytoses with a topical administration .
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- HY-U00311
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- HY-N1914S
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L-(+)-Ergothioneine-d3
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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Ergothioneine-d3 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
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- HY-N1914S1
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L-(+)-Ergothioneine-d9
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Endogenous Metabolite
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Others
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Ergothioneine-d9 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
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- HY-B0293A
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Butoconazole, an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
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- HY-10882
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- HY-W115276
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Bacterial
Fungal
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Infection
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Fenticonazole is an imidazole derivative with antibacterial and antifungal activity. Fenticonazole has the potential for the research of mixed vaginitis .
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- HY-B0293
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RS 35887
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Fungal
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Infection
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Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis .
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- HY-N1914
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L-(+)-Ergothioneine
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Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity .
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- HY-W764737
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Isotope-Labeled Compounds
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Cancer
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Methylboronic acid pinacol ester is an orally administered compound that inhibits the activity of peptidases and imidazole derivatives. Methylboronic acid pinacol ester is used as a medicinal preparation for cancer .
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- HY-106541
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Fungal
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Infection
Cancer
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Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects .
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- HY-128365
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Fungal
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Infection
Cancer
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Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride has anti-infection and anti-cancer effects .
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- HY-B0163
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- HY-B0163A
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- HY-B1460
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(±)-Sulconazole mononitrate
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Sulconazole mononitrate ((±)-Sulconazole mononitrate), an imidazole derivative, is a broad-spectrum fungicide. Sulconazole mononitrate can be used for the research of dermatomycoses, pityriasis versicolor, and cutaneous candidiasis .
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- HY-10882S
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- HY-10882R
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Fungal
Bacterial
Autophagy
Antibiotic
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Infection
Cancer
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Clotrimazole (Standard) is the analytical standard of Clotrimazole. This product is intended for research and analytical applications. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
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- HY-10882S1
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- HY-B0319
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UK-20349
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Fungal
Antibiotic
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Infection
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Tioconazole (UK-20349) is an antifungal imidazole derivative with broad spectrum activity. Tioconazole has inhibitory active aginst several dermatophytes and several yeasts with MIC50s <3.12 mg/L and <9 mg/L, respectively .
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- HY-Y1055
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Guanine
3 Publications Verification
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DNA/RNA Synthesis
Endogenous Metabolite
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Cancer
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Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool .
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- HY-B0359
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REC 15-1476
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Fungal
Antibiotic
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Infection
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Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis .
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- HY-Y1055S
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DNA/RNA Synthesis
Endogenous Metabolite
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Cancer
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Guanine- 13C is the 13C labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-162271
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Topoisomerase
Fungal
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Infection
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Antibacterial agent 187 (IKE7) is a derivative containing imidazole and triazolacridone structures that target yeast topoisomerase II. Antibacterial agent 187 has antifungal activity and MIC value of resistance to fluconazole (HY-B0101) is 32-64 μg/mL .
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- HY-Y1055S3
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- HY-Y1055S4
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- HY-119427
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Others
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Cancer
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Anti-melanoma agent 3 (compound 5cb) is a 2-aryl-4-benzoyl-imidazole (ABI) derivative and an inhibitor of melanoma xenogeneic tumors. Anti-melanoma agent 3 exerts anticancer activity by interacting with the colchicine binding site to inhibit tubulin polymerization .
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- HY-Y1055S1
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DNA/RNA Synthesis
Endogenous Metabolite
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Cancer
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Guanine- 13C, 15N2 is the 13C and 15N labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-144650
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Apoptosis
HSP
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Cancer
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Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol−imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits Hsp90−Cdc37 by covalent-binding, and induces apoptosis .
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- HY-Y1055S2
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Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
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Cancer
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Guanine- 13C5, 15N5 is 13C and 15N-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-106019C
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R75251 dihydrochloride
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Cytochrome P450
RAR/RXR
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Metabolic Disease
Inflammation/Immunology
Cancer
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Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties .
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- HY-106019
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R75251
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Cytochrome P450
RAR/RXR
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Metabolic Disease
Inflammation/Immunology
Cancer
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Liarozole (R75251; R85246) is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid (IC50=7 μM), resulting in increased tissue levels of retinoic acid. Liarozole shows antitumoral properties .
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- HY-115905
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Parasite
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Infection
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Antimalarial agent 9 (Compound 11) is a potent antimalarial agent. Antimalarial agent 9 is a quinoline-imidazole derivative compound. Antimalarial agent 9 exhibits significant antimalarial efficacy in-vitro against both CQ-sensitive (IC50-0.14 μM) and MDR strain (IC50-0.41 μM) with minimal cytotoxicity and high selectivity .
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- HY-134622
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CDK
GSK-3
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Neurological Disease
Cancer
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GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a. GSK-3/CDK5/CDK2-IN-1 can be used for the research of cancer, and neurodegenerative diseases .
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- HY-161153
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Apoptosis
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Cancer
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Microtubule inhibitor 9 (Compound O-7) is a 2-Aryl-1H-benzo [d] imidazole derivative with in vitro anticancer activity. Microtubule inhibitor 9 can induce cell cycle arrest at the G2/M phase and early apoptosis. Microtubule inhibitor 9 inhibits cancer cell migration by inhibiting wound healing and colony formation .
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- HY-144034
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GCGR
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Metabolic Disease
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GLP-1R agonist 3 is a potent agonist of GLP-1R. GLP-1R agonist 3 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 3 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 1) .
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- HY-144033
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GCGR
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Metabolic Disease
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GLP-1R agonist 1 is a potent agonist of GLP-1R. GLP-1R agonist 1 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 1 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 4) .
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- HY-66019
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FITC
Maximum Cited Publications
35 Publications Verification
Fluorescein 5-isothiocyanate
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Fluorescent Dye
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Others
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FITC (Fluorescein Isothiocyanate), is one of the green fluorescein derivatives widely used in biology. FITC has the characteristics of high absorptivity, excellent fluorescence quantum yield and good water solubility. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. In addition to its use as a protein marker, FITC can also be used as a fluorescent protein tracer to rapidly identify pathogens by labeling antibodies, or for microsequencing of proteins and peptides (HPLC). The maximum excitation wavelength of FITC is 494 nm. Once excited, it fluoresces yellow-green at a maximum emission wavelength of 520 nm.
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Cat. No. |
Product Name |
Type |
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- HY-66019
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Fluorescein 5-isothiocyanate
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Fluorescent Dyes/Probes
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FITC (Fluorescein Isothiocyanate), is one of the green fluorescein derivatives widely used in biology. FITC has the characteristics of high absorptivity, excellent fluorescence quantum yield and good water solubility. The isothiocyanate group of FITC can be combined with amino, sulfhydryl, imidazole, tyrosyl, carbonyl and other groups on the protein, so as to achieve protein labeling including antibodies and lectins. In addition to its use as a protein marker, FITC can also be used as a fluorescent protein tracer to rapidly identify pathogens by labeling antibodies, or for microsequencing of proteins and peptides (HPLC). The maximum excitation wavelength of FITC is 494 nm. Once excited, it fluoresces yellow-green at a maximum emission wavelength of 520 nm.
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Cat. No. |
Product Name |
Type |
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- HY-D0837
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Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene
|
Biochemical Assay Reagents
|
Imidazole, a highly polar compound containing planar five-membered rings, has been widely used as a corrosion inhibitor. Derivatives of Imidazole have antimicrobial, anti-inflammatory, and antitumor activities .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-N1914S1
-
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Ergothioneine-d9 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
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- HY-N1914S
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Ergothioneine-d3 is the deuterium labeled Ergothioneine. Ergothioneine, an imidazole-2-thione derivative of histidine betaine, is synthesized by certain bacteria and fungi. Ergothioneine is generally considered an antioxidant[1].
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- HY-W764737
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Methylboronic acid pinacol ester is an orally administered compound that inhibits the activity of peptidases and imidazole derivatives. Methylboronic acid pinacol ester is used as a medicinal preparation for cancer .
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- HY-10882S
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Clotrimazole-d5 is the deuterium labeled Clotrimazole. Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity[1][2].
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- HY-10882S1
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Clotrimazole-d10 is deuterated labeled Clotrimazole (HY-10882). Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity.
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- HY-Y1055S
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Guanine- 13C is the 13C labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-Y1055S3
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Guanine- 15N5 is 15N labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-Y1055S4
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Guanine- 13C5 is 13C-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-Y1055S1
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Guanine- 13C, 15N2 is the 13C and 15N labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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- HY-Y1055S2
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Guanine- 13C5, 15N5 is 13C and 15N-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
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